PE Mouse Anti-Mouse CD45.1

产品名称:PE 小鼠抗小鼠 CD45.1 抗体；PE Mouse Anti-Mouse CD45.1

中文名称:PE 小鼠抗小鼠 CD45.1 抗体

英文名称:PE Mouse Anti-Mouse CD45.1

PE Mouse Anti-Mouse CD45.1 产品介绍：

Material Number: 553776
Size: 0.2 mg
Concentration: 0.2 mg/ml
Clone: A20
Immunogen: SJL mouse thymocytes and splenocytes
Isotype: Mouse (A.SW) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.


PE Mouse Anti-Mouse CD45.1 Description：

The A20 monoclonal antibody specifically binds to CD45 (Leukocyte Common Antigen) on all leukocytes of mouse strains expressing the
CD45.1 alloantigen (eg, RIII, SJL/J, STS/A, DA). This alloantigen was originally named Ly-5.2, and this was the designation at the time that
the antibody was characterized. The designation was later changed from Ly-5.2 to Ly-5.1 to conform with the convention that the .2
alloantigen designations be assigned to the C57BL/6 strain. mAb A20 has been reported not to react with leukocytes of most other mouse
strains, which express the CD45.2 alloantigen. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular
(COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of
exons 4, 5, and 6 (designated A, B, and C, respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are
cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal
transduction. The A20 antibody has been reported to inhibit some responses of B cells, from mice expressing the CD45.1 alloantigen, to
antigens and LPS.

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.