APC Rat Anti-Mouse CD117

产品名称:APC 大鼠抗小鼠 CD117 抗体；APC Rat Anti-Mouse CD117

中文名称:APC 大鼠抗小鼠 CD117 抗体

英文名称:APC Rat Anti-Mouse CD117

APC Rat Anti-Mouse CD117 产品介绍：

Material Number: 553356
Alternate Name: c-KIT; W; SCFR; Stem Cell Factor Receptor; Sl; Steel Factor Receptor; Ssm
Size: 0.1 mg
Concentration: 0.2 mg/ml
Clone: 2B8
Immunogen: Mouse Bone Marrow Mast Cells
Isotype: Rat (WI) IgG2b, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium 
azide



APC Rat Anti-Mouse CD117 Description：

The 2B8 monoclonal antibody specifically binds to CD117 (c-Kit), a transmembrane tyrosine-kinase receptor that is encoded by the Kit gene 
(formerly dominant white spotting, W). The c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor) encoded by 
the Kit1 gene (formerly steel, SI), is a co-mitogen for hematopoietic stem cells, myeloerythroid progenitors and a mast-cell differentiation 
factor. The KitW and Kit1SI mutant alleles have similar pleiotropic effects on the development of melanocytes, germ cells, and the 
hematopoietic system. In the ***** bone marrow, CD117 is expressed on hematopoietic progenitor cells, including CD90 (Thy-1) low, 
TER-119-, CD45R/B220-, CD11b (Mac-1)-, Ly-6G (Gr-1)-, CD4-, CD8-, and Sca-1 (Ly-6A/E)+ multipotent hemotopoietic stem cells, 
progenitors committed to myeliod and/or erythroid lineages, and precursors of B and T lymphocytes. This widespread expression of CD117 in 
hematopoietic precursors is consistent with the participation of c-Kit and its ligand in the regulation of several hematopoietic lineages. 
Intrathymic expression of c-Kit and c-Kit ligand suggest that CD117 is also involved in the regulation of some events during the development 
of T lymphocytes. CD117 is also expressed by mast cells and by dendritic cells found in the periarteriolar lymphocytoc sheaths (T-cell areas) 
of splenic white pulp. The mAb 2B8 reportedly does not block the action of c-Kit. This clone 2B8 had been reported that there was 
cross-reactivity with rat.

APC Rat Anti-Mouse CD117 Preparation and Storage：

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated to APC under optimum conditions, and unconjugated antibody and free APC were removed