PE Hamster Anti-Mouse CD61

产品名称:PE 仓鼠抗小鼠 CD61 抗体；PE Hamster Anti-Mouse CD61

中文名称:PE 仓鼠抗小鼠 CD61 抗体

英文名称:PE Hamster Anti-Mouse CD61

PE Hamster Anti-Mouse CD61 产品介绍：

Material Number: 553347
Alternate Name: Integrin β3 chain
Size: 0.2 mg
Concentration: 0.2 mg/ml
Clone: 2C9.G2
Immunogen: Mouse T-cell Hybridoma 2B4 Vitronectin Receptor
Isotype: Armenian Hamster IgG1, κ
Reactivity: QC Testing: Mouse
Tested in Development: Rat
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.

The 2C9.G2 antibody reacts with the integrin β3 chain (CD61), which associates with the integrin αv chain (CD51) to form the vitronectin 
receptor and with the αIIb chain (CD41) to form the gpIIb/IIIa complex. Both receptors mediate adhesion to fibronectin, fibrinogen, 
vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is also mediated by the binding of αvβ3 integrin or 
vitronectin receptor to CD31 (PECAM-1). In addition, interaction of the αvβ3 integrin with its ligands regulates the L-type Ca2+ channel in 
vascular smooth muscle cells, possibly mediating vasodilatory responses to injury. Soluble and insoluble 2C9.G2 mAb mimics the effect of the 
natural ligands in smooth muscle cells from rat cremaster arterioles. Furthermore, osteopontin, also named Eta-1, is a cytokine that binds to 
αvβ3. CD61 is expressed on platelets, activated T lymphocytes, polymorphonuclear granulocytes, and blastocysts. Cross-reactivity of mAb 
2C9.G2 to rat mast cells and platelets has been observed by flow cytometric analysis. mAb 2C9.G2 has been demonstrated to block binding of 
rat and mouse cells to fibronectin. 

PE Hamster Anti-Mouse CD61 Preparation and Storage：

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.