Biotin Rat Anti-Mouse CD11b

产品名称:Biotin 大鼠抗小鼠 CD11b 抗体；Biotin Rat Anti-Mouse CD11b

中文名称:Biotin 大鼠抗小鼠 CD11b

英文名称:Biotin Rat Anti-Mouse CD11b

Biotin Rat Anti-Mouse CD11b 产品介绍：

Material Number: 553309
Alternate Name: Integrin α[M] chain, Mac-1 α chain, CR3
Size: 0.5 mg
Concentration: 0.5 mg/ml
Clone: M1/70
Immunogen: C57BL/10 splenic T cells and concanavalin A-activated C57BL/10 splenocytes
Isotype: Rat (DA) IgG2b, κ
Reactivity:QC Testing: Mouse
Reported: Human
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.


Biotin Rat Anti-Mouse CD11b Description：

The M1/70 antibody reacts with the 170 kDa α[M] chain of Mac-1 (CD11b/CD18, α[M]β2 integrin), also known as complement receptor 3 
(CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed at varying levels on granulocytes, macrophages, 
myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 cells. Mac-1 expression is rapidly up-regulated on neutrophils after 
activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. M1/70 antibody reportedly blocks cell adherence and 
C3bi binding, but it does not block cell-mediated lysis. Cross-reaction of mAb M1/70 with CD11b on human monocytes, polymorphonuclear 
leukocytes, and NK cells has been reported. 

Biotin Rat Anti-Mouse CD11b Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.