产品名称:FITC 大鼠抗小鼠 CD45 抗体;FITC Rat Anti-Mouse CD45
中文名称:FITC 大鼠抗小鼠 CD45 抗体
英文名称:FITC Rat Anti-Mouse CD45
FITC Rat Anti-Mouse CD45 产品介绍:
Material Number: 553079 Alternate Name: Leukocyte Common Antigen (LCA), Ly-5, T200 Size: 0.1 mg Concentration: 0.5 mg/ml Clone: 30-F11 Immunogen: Mouse Thymus / Spleen Isotype: Rat (LOU) IgG2b, κ Reactivity: QC Testing: Mouse Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.
The 30-F11 clone has been reported to react with all isoforms and both alloantigens of CD45, which is found on hematopoietic stem cells and all cells of hematopoietic origin, except erythrocytes. CD45 is a transmembrane glycoprotein which is expressed at high levels on the cell-surface, and its presence distinguishes leukocytes from non-hematopoietic cells. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family, where the intracellular carboxy-terminal region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated as A, B, and C, respectively). CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction and the CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific.
FITC Rat Anti-Mouse CD45 Preparation and Storage:
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed. Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.
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