Biotin Hamster Anti-Mouse CD3e

产品名称:Biotin 仓鼠抗小鼠 CD3e 抗体；Biotin Hamster Anti-Mouse CD3e

中文名称:Biotin 仓鼠抗小鼠 CD3e 抗体

英文名称:Biotin Hamster Anti-Mouse CD3e

Biotin Hamster Anti-Mouse CD3e 产品介绍：

Material Number: 553060
Alternate Name: CD3ε chain
Size: 0.5 mg
Concentration: 0.5 mg/ml
Clone: 145-2C11
Immunogen: H-2Kb specific cytotoxic T lymphocyte clone BM10-37
Isotype: Armenian Hamster IgG1, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.


Biotin Hamster Anti-Mouse CD3e Description：

The 145-2C11 antibody reacts with the 25-kDa ε chain of the T-cell receptor-associated CD3 complex, which is expressed on thymocytes, 
mature T lymphocytes, and NK-T cells. The cytoplasmic domain of CD3e participates in the signal transduction events which activate several 
cellular biochemical pathways as a result of antigen recognition. Soluble 145-2C11 antibody can activate either unprimed (naive) or primed 
(memory/preactivated) T cells in vivo or in vitro, in the presence of Fc receptor-bearing accessory cells. In contrast, plate-bound 145-2C11 
can activate T cells in the absence of accessory cells. Soluble 145-2C11 antibody has been reported to induce re-directed lysis of Fc 
receptor-bearing target cells by CTL clones and can also block lysis of specific target cells by antigen-specific CTL's. Under some conditions, 
T-cell activation by 145-2C11 antibody has been reported to result in apoptotic cell death. The 145-2C11 antibody does not cross-react with 
rat leukocytes and it has been reported that pre-incubation of thymus cell suspensions at 37°C for 2-4 hours prior to staining enhances the 
ability of anti-CD3ε and anti-αβ TCR mAbs to detect the T-cell receptor on immature thymocytes.

Biotin Hamster Anti-Mouse CD3e Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.