PerCP-Cy™5.5 Mouse Anti-Mouse CD45.2

产品名称:PerCP-Cy™5.5 小鼠抗小鼠 CD45.2 抗体；PerCP-Cy™5.5 Mouse Anti-Mouse CD45.2

中文名称:PerCP-Cy™5.5 小鼠抗小鼠 CD45.2 抗体

英文名称:PerCP-Cy™5.5 Mouse Anti-Mouse CD45.2

PerCP-Cy™5.5 Mouse Anti-Mouse CD45.2 产品介绍：

Material Number: 552950
Alternate Name: Ly-5.2; T200; LCA; Leukocyte common antigen; Ptprc
Size: 0.1 mg
Concentration: 0.2 mg/ml
Clone: 104
Immunogen: B10.S mouse thymocytes and splenocytes
Isotype: Mouse (SJL) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium 
azide.


PerCP-Cy™5.5 Mouse Anti-Mouse CD45.2 Description：

The 104 clone has been reported to react with CD45 (Leukocyte Common Antigen) on all leukocytes of most mouse strains (eg, A, AKR, BALB/c, CBA/Ca, CBA/J, C3H/He, C57BL, C57BR, C57L, C58, DBA/1, DBA/2, NZB, SWR, 129). This alloantigen was originally named Ly-5.1, and this was the designation at the time that the antibody was characterized. The designation was later changed from Ly-5.1 to Ly-5.2 to conform with the convention that the .2 alloantigen designations be assigned to the C57BL/6 strain. mAb 104 has been reported not to react with leukocytes of the mouse strains expressing the CD45.1 alloantigen (eg, RIII, SJL/J, STS/A, and DA). CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C, respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. The 104 antibody has been reported to inhibit some responses of B cells, from mice expressing the CD45.2 alloantigen, to certain antigens and LPS. In addition, reduction of serum IgG levels and amelioration of autoimmune renal pathology were reported in mAb 104-treated systemic lupus erythematosus-prone mice.

PerCP-Cy™5.5 Mouse Anti-Mouse CD45.2 Preparation and Storage：

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with PerCP-Cy5.5 under optimum conditions, and unconjugated antibody and free PerCP-Cy5.5 were removed. Storage of PerCP-Cy5.5 conjugates in unoptimized diluent is not recommended and may result in loss of signal intensity.