PE-Cy™7 Rat Anti-Mouse CD19

产品名称:PE-Cy™7 大鼠抗小鼠 CD19 抗体；PE-Cy™7 Rat Anti-Mouse CD19

中文名称:PE-Cy™7 大鼠抗小鼠 CD19 抗体

英文名称:PE-Cy™7 Rat Anti-Mouse CD19

PE-Cy™7 Rat Anti-Mouse CD19 产品介绍：

Material Number: 552854
Size: 0.1 mg
Concentration: 0.2 mg/ml
Clone: 1D3
Immunogen: Mouse CD19 Transfected Cell Line
Isotype: Rat (LEW) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.

The 1D3 antibody reacts with CD19, a B lymphocyte-lineage differentiation antigen. CD19, a 95-kDa transmembrance glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature B-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular activation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells in the bone marrow and periphery. B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice. Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of conventional B lymphocytes in the periphery. CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B cells and regulation of tolerance. CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to play a role in complement-mediated mast-cell activation.

PE-Cy™7 Rat Anti-Mouse CD19 Preparation and Storage：

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with PE-Cy7 under optimum conditions, and unconjugated antibody and free PE-Cy7 were removed.