产品名称:FITC 小鼠抗人 CD209 抗体;FITC Mouse Anti-Human CD209
中文名称:FITC 小鼠抗人 CD209 抗体
英文名称:FITC Mouse Anti-Human CD209
FITC Mouse Anti-Human CD209 产品介绍:
Material Number: 551264 Alternate Name: DC-SIGN Size: 100 tests Vol. per Test: 20 µl Clone: DCN46 Immunogen: Human Monocyte Derived DC Cells Isotype: Mouse IgG2b, κ Reactivity: QC Testing: Human Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide. FITC Mouse Anti-Human CD209 Description:
The DCN46 antibody reacts with dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN or CD209), a type-II membrane protein of approximately 44 kDa with a mannose-binding C-type lectin domain. It is highly expressed on dendritic cells in mucosal tissues. Its sequence is identical to the HIV-1 envelope gp120-binding C-type lectin, and reports suggest that DC-SIGN binds to HIV-1 gp120 and effectively transmits infectious HIV-1 to resting T lymphocytes expressing CD4 and chemokine receptors. The C-type lectin domain of DC-SIGN is also capable of binding other pathogenic viruses, bacteria, and parasites. Reports also suggest that DC-SIGN enables the highly efficient migration of dendritic cells from blood into the tissues. It can interact with ICAM-2, which has a similar sequence as ICAM-3, and is abundantly expressed on vascular and lymphoid endothelium. Thus, DC-SIGN mediates dendritic cells rolling and transendothelial migration, and its interaction with ICAM-2 is essential to specific migratory functions of dendritic cells.
FITC Mouse Anti-Human CD209 Preparation and Storage:
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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