PerCP-Cy™5.5 Rat Anti-Mouse CD11b

产品名称:PerCP-Cy™5.5 大鼠抗小鼠 CD11b 抗体；PerCP-Cy™5.5 Rat Anti-Mouse CD11b

中文名称:PerCP-Cy™5.5 大鼠抗小鼠 CD11b 抗体

英文名称:PerCP-Cy™5.5 Rat Anti-Mouse CD11b

PerCP-Cy™5.5 Rat Anti-Mouse CD11b 产品介绍：

Material Number: 550993
Alternate Name: CR-3 alpha chain; Itgam; Integrin alpha M; Ly-40; Mac-1 alpha
Size: 0.1 mg
Concentration: 0.2 mg/ml
Clone: M1/70
Immunogen: Mouse Splenic Cells
Isotype: Rat (DA) IgG2b, κ
Reactivity: QC Testing: Mouse
Reported: Human
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.

The M1/70 antibody reacts with the 170-kDa α[M] chain of Mac-1 (CD11b/CD18, α[M]β[2] integrin), also known as complement receptor 3 
(CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 cells. Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. M1/70 antibody reportedly blocks cell adherence and C3bi binding, but it does not block cell-mediated lysis. Cross-reaction of mAb M1/70 with CD11b on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported. 

PerCP-Cy™5.5 Rat Anti-Mouse CD11b Preparation and Storage：

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with PerCP-Cy5.5 under optimum conditions, and unconjugated antibody and free PerCP-Cy5.5 were 
removed. Storage of PerCP-Cy5.5 conjugates in unoptimized diluent is not recommended and may result in loss of signal intensity.