PE Rabbit Anti- Active Caspase-3

产品名称:PE Rabbit Anti- Active Caspase-3

PE Rabbit Anti- Active Caspase-3 产品介绍：

Material Number: 550821
Alternate Name: CPP32; Yama; Apopain
Size: 100 tests
Vol. per Test: 20 µl
Clone: C92-605
Isotype: Rabbit IgG
QC Testing: Human
Tested in Development: Mouse
Reactivity:
Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
PE Rabbit Anti- Active Caspase-3 Description：

The caspase family of cysteine proteases plays a key role in apoptosis and inflammation. Caspase-3 is a key protease that is activated during
the early stages of apoptosis and, like other members of the caspase family, is synthesized as an inactive pro-enzyme that is processed in cells
undergoing apoptosis by self-proteolysis and/or cleavage by another protease. The processed forms of caspases consist of large (17-22 kDa)
and small (10-12 kDa) subunits which associate to form an active enzyme. Active caspase-3, a marker for cells undergoing apoptosis, consists
of a heterodimer of 17 and 12 kDa subunits which is derived from the 32 kDa pro-enzyme. Active caspase-3 proteolytically cleaves and
activates other caspases, as well as relevant targets in the cytoplasm, e.g., D4-GDI and Bcl-2, and in the nucleus (e.g. PARP). This antibody
has been reported to specifically recognize the active form of caspase-3 in human and mouse cells. It has not been reported to recognize the
pro-enzyme form of caspase-3.

PE Rabbit Anti- Active Caspase-3 Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

PE Rabbit Anti- Active Caspase-3 Suggested Companion Products：

Catalog Number Name Size Clone
554714 BD Cytofix/Cytoperm™ Fixation/Permeablization Kit 250 tests (none)