PE Rat Anti-Mouse CD8b

产品名称:PE Rat Anti-Mouse CD8b；PE Rat Anti-Mouse CD8b

中文名称:PE 大鼠抗小鼠 CD8b 抗体

英文名称:PE Rat Anti-Mouse CD8b

PE Rat Anti-Mouse CD8b 产品介绍：

Material Number: 550798
Alternate Name: Ly-3
Size: 0.1 mg
Concentration: 0.2 mg/ml
Clone: H35-17.2
Immunogen: 5-day MLR, C57BL/6 anti-BALB/c
Isotype: Rat IgG2b, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide
PE Rat Anti-Mouse CD8b Description：

The H35-17.2 antibody reacts with both alloantigeneic forms of the β chain of the CD8 differentiation antigen (Ly-3 or Lyt- 3). The CD8 α
and α' chains (CD8a) form heterodimers with the CD8 β chain (CD8b, Ly-3, or Lyt-3) on the surface of most thymocytes. A subpopulation of
mature T lymphocytes (i.e., MHC class I-restricted T cells, including most T suppressor/cytotoxic cells) expresses almost exclusively the CD8
αβ heterodimer (the α' chain is absent). Subsets of γδ TCR-bearing T cells, intestinal intraepithelial lymphocytes, and dendritic cells express
CD8a without CD8b. It has been suggested that the expression of the CD8a/CD8b heterodimer is restricted to T lymphocytes which matured
in the thymus or in an extrathymic environment that had been influenced by thymus- initiated neuroendocrine signals. CD8 is an antigen
coreceptor on the T-cell surface which interacts with MHC class I molecules on antigen-presenting cells. It participates in T-cell activation
through its association with the T-cell receptor complex and protein tyrosine kinase lck (p56lck). The H35-17.2 mAb blocks T-cell-mediated
cytolysis of allogeneic lymphoma cells.

PE Rat Anti-Mouse CD8b Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.