Corticotropin Releasing Factor bovine，≥90% (HPLC)|92307-52-3|产品详情|供应商

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产品名称：Corticotropin Releasing Factor bovine，≥90% (HPLC)|92307-52-3|产品详情|供应商

别名: CRF, CRH
Cas号: 92307-52-3
分子式: C206H340N60O63S
介绍:  氨基酸序列 Ser-Gln-Glu-Pro-Pro-Ile-S?er-Leu-Asp-Leu-Thr-Phe-Hi?s-Leu-Leu-Arg-Glu-Val-Leu?-Glu-Met-Thr-Lys-Ala-Asp-?Gln-Leu-Ala-Gln-Gln-Ala-H?is-Asn-Asn-Arg-Lys-Leu-Le?u-Asp-Ile-Ala Corticotropin Releasing Factor,bovine, (C206H340N60O63S1), a peptide with the sequence H2N-SQEPPISLDLTFHLLREVLEMTKADQLAQQAHNNRKLLDIA-amide, MW= 4697.4. Corticotropin-releasing hormone (CRH) also known as corticotropin-releasing factor (CRF) is a peptide hormone and neurotransmitter involved in the stress response. It belongs to corticotropin-releasing factor family(1). Its main function is the stimulation of the pituitary synthesis of ACTH.Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 196-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Increased CRH production has been observed to be associated with Alzheimer's disease and major depression(2), and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to being produced in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta, CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition.
贮存:  储存温度:-20°C
生化和生理学机理:  CRF是一种是由垂体前叶释放促肾上腺皮质**和内啡肽的下丘脑肽。在**神经系统中它也是一种神经递质，涉及自主神经和***对刺激的反应。

包装：0.5mg 1mg 2.5mg
单位：瓶

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